sub-isophane amount
Russian translation: субизофанное содержание
| 03:10 Nov 12, 2022 |
| English to Russian translations [PRO] Medical - Medical: Pharmaceuticals / Preclinical Development | |||||||
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|  Selected response from: Marlin31 Russian Federation Local time: 14:51 | ||||||
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| 3 | субизофанное содержание |
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Answers
5 hrs confidence: 
субизофанное содержание Explanation: субизофанное содержание https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984539/ NPH insulin Neutral Protamine Hagedorn (NPH), introduced by Hagedorn in 1946, contains protamine and insulin in ‘isophane’ amount, i.e., there is neither an excess of protamine nor of insulin. https://bliznesy.ru/preparaty/rinsulin-r.html Аббревиатура «НПХ» расшифровывается как нейтральный протамин Хагедорна – вещество, созданное датчанином Хансом Хагедроном, отличительной особенностью которого является равное (изофанное) содержание искусственно синтезированного инсулинового человеческого гормона и протамина. -------------------------------------------------- Note added at 6 час (2022-11-12 09:41:21 GMT) -------------------------------------------------- Есть еще один термин, который также полезен в понимании того, что такое "(суб)изофанное содержание": isophane ratio https://www.jstor.org/stable/3001435 The isophane-ratio is that ratio of insulin to protamine which results in equilibrium amounts of insulin and protamine remaining in the supernatant as tested by nephelometric procedures. https://patents.justia.com/patent/5461031 The term "isophane ratio" is the equilibrium amount of protamine necessary to complex with the analog as taught by Krayenbuhl and Rosenberg, STENO MEMORIAL HOSPITAL REPORT (COPENHAGEN), 1:60 (1946). The isophane ratio is determined by titration in a manner well known in the art and described in Krayenbuhl, et al. |
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