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  3. Medical (general)

adherir

English translation: cleaving

09:24 Nov 10, 2023
Spanish to English translations [PRO]
Medical - Medical (general)
Spanish term or phrase: adherir
Estos anticoagulantes orales, incluidos el dabigatrán, rivaroxabán, el apixabán y el edoxabán, evitan que el factor Xa adhiera la protrombina a la trombina y se una directamente al factor Xa, a diferencia de la heparina, que potencia la actividad de la antitrombina III

This doesn't seem to make a lot of sense, as factor Xa does not attach prothrombin to thrombin (and then bind directly to ... factor Xa?) Help would be appreciated!
Jeff Steffin
Local time: 15:55
English translation:cleaving
Explanation:
In the normal physiological state of the human body, there are coagulation systems and fibrinolysis systems in the blood that resist each other. These two systems are in the process of dynamic equilibrium, which enables the blood to have a potential coagulation function and ensures that the blood is always in a fluid state. However, under the influence of certain factors (such as vascular endothelial injury, abnormal activation of the coagulation system, changes in blood flow, etc.), this dynamic balance is broken, so that blood coagulation or some formed components in the blood adhere to each other, the above process leads to the formation of thrombus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485664/

What Are Factor Xa Inhibitors?
They’re in a class of blood thinners called direct oral anticoagulants, or DOACs. They work by targeting tiny molecules called factor Xa, a substance that helps the platelets, cells, and proteins in your blood stick together, or clot.

Factor Xa inhibitors block the final step needed to make thrombin. That’s an enzyme in your blood that turns something called fibrinogen into fibrin, which helps you close up wounds. People whose bodies make a lot of thrombin seem to be more likely to have recurrent DVT or PE.

You can get factor Xa inhibitors with a prescription from your doctor.

https://www.webmd.com/dvt/factor-xa-inhibitors-for-dvt

Prothrombin is transformed into thrombin by a clotting factor known as factor X or prothrombinase; thrombin then acts to transform fibrinogen, also present in plasma, into fibrin, which, in combination with platelets from the blood, forms a clot (a process called coagulation). Under normal circumstances, prothrombin is changed into thrombin only when injury occurs to the tissues or circulatory system or both; therefore, fibrin and blood clots are not formed except in response to bleeding.

https://www.britannica.com/science/prothrombin

I've just found this :-)

'These agents prevent factor Xa from cleaving prothrombin to form thrombin and bind directly to factor Xa, rather than enhancing the activity of antithrombin.'

https://www.uspharmacist.com/article/assessing-novel-oral-an...

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Note added at 1 hr (2023-11-10 10:45:50 GMT) Post-grading
--------------------------------------------------

Glad to be of help :-) I hope you didn't waste too much time trying to decipher the source text.
Selected response from:

Helena Chavarria
Spain
Local time: 00:55
Grading comment
Perfect thanks for that reference you just found, it's perfect. The source text obviously had a mistake.
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +2conform to
Muriel Vasconcellos
4 +2cleaving
Helena Chavarria


  

Answers


39 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
conform to


Explanation:
From Linguee: adherir (~ a algo, ~ algo a algo) verbo
...
menos frecuente:
stick v · bond v · subscribe v · accede to sth. v · affix sth. to sth. v · **conform to sth. v**

Muriel Vasconcellos
United States
Local time: 15:55
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 1508
Notes to answerer
Asker: Unfortunately, your answer doesn't fit in this context, it would seem, but thanks so much, in another context it would have worked.


Peer comments on this answer (and responses from the answerer)
agree  Michelle Wright: In the context of science and molecules. It means that something bonds to or sticks to the other compound. "adhiera la protrombina a la trombina" to bond to, to stick to, cleaves to, attaches to the cleavage of two peptide bonds in prothrombin (Arg274-
1 hr
agree  Andrew Bramhall
1 hr
Login to enter a peer comment (or grade)

50 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
cleaving


Explanation:
In the normal physiological state of the human body, there are coagulation systems and fibrinolysis systems in the blood that resist each other. These two systems are in the process of dynamic equilibrium, which enables the blood to have a potential coagulation function and ensures that the blood is always in a fluid state. However, under the influence of certain factors (such as vascular endothelial injury, abnormal activation of the coagulation system, changes in blood flow, etc.), this dynamic balance is broken, so that blood coagulation or some formed components in the blood adhere to each other, the above process leads to the formation of thrombus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485664/

What Are Factor Xa Inhibitors?
They’re in a class of blood thinners called direct oral anticoagulants, or DOACs. They work by targeting tiny molecules called factor Xa, a substance that helps the platelets, cells, and proteins in your blood stick together, or clot.

Factor Xa inhibitors block the final step needed to make thrombin. That’s an enzyme in your blood that turns something called fibrinogen into fibrin, which helps you close up wounds. People whose bodies make a lot of thrombin seem to be more likely to have recurrent DVT or PE.

You can get factor Xa inhibitors with a prescription from your doctor.

https://www.webmd.com/dvt/factor-xa-inhibitors-for-dvt

Prothrombin is transformed into thrombin by a clotting factor known as factor X or prothrombinase; thrombin then acts to transform fibrinogen, also present in plasma, into fibrin, which, in combination with platelets from the blood, forms a clot (a process called coagulation). Under normal circumstances, prothrombin is changed into thrombin only when injury occurs to the tissues or circulatory system or both; therefore, fibrin and blood clots are not formed except in response to bleeding.

https://www.britannica.com/science/prothrombin

I've just found this :-)

'These agents prevent factor Xa from cleaving prothrombin to form thrombin and bind directly to factor Xa, rather than enhancing the activity of antithrombin.'

https://www.uspharmacist.com/article/assessing-novel-oral-an...

--------------------------------------------------
Note added at 1 hr (2023-11-10 10:45:50 GMT) Post-grading
--------------------------------------------------

Glad to be of help :-) I hope you didn't waste too much time trying to decipher the source text.

Helena Chavarria
Spain
Local time: 00:55
Native speaker of: Native in EnglishEnglish
PRO pts in category: 381
Grading comment
Perfect thanks for that reference you just found, it's perfect. The source text obviously had a mistake.

Peer comments on this answer (and responses from the answerer)
agree  neilmac
9 hrs
  -> Cheers, Neil :-)
agree  liz askew
1 day 6 hrs
  -> Thank you, Liz
Login to enter a peer comment (or grade)



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